Abstract: The Negative Effect of Tumescent Lidocaine on Lipoaspirate Stem Cell Survival
نویسندگان
چکیده
INTRODUCTION: Mechanical processing of lipoaspirate (LA) is a commonly employed technique prior to reinjection for the purposes of lipofilling and skin rejuvenation. Our group has previously demonstrated that one form of mechanical processing, ‘nanofat grafting,’ results in a significant upregulation of multipotent mesenchymal stem cell (MSC) markers, adipose-derived stem (ADSCs) and endothelial progenitor cell populations (EPCs). Recently, a pluripotent population termed multilineage stress-enduring (Muse) cells was described after subjecting lipoaspirate to various extreme stress conditions. Based on these findings, we hypothesized that modulation of shear-stress alone would result in a correlative induction of markers associated with multipotency and/or pluripotency.
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Tumescent Liposuction without Lidocaine
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